Impact of mutations on the stability of SARS-CoV-2 nucleocapsid protein structure

Nelli Muradyan, Vahram Arakelov, Arsen Sargsyan, Adrine Paronyan, Grigor Arakelov, Karen Nazaryan The nucleocapsid (N) protein of SARS-CoV-2 is known to participate in various host cellular processes, including interferon inhibition, RNA interference, apoptosis, and regulation of virus life cycles. Additionally, it has potential as a diagnostic antigen and/or immunogen. Our research focuses on examining structural …

In Silico Study of Pyrin and 14-3-3 Protein Modulation During FMF and PAAND

Adrine Paronyan, Nelli Muradyan, Arsen Sargsyan, Vahram Arakelov, Grigor Arakelov, Karen Nazaryan Familial Mediterranean fever (FMF) is a genetically determined disease transmitted through autosomal recessive inheritance. Recently, a rare but similar disease to FMF, pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND), has been discovered. PAAND is inherited dominantly and is characterized by neutrophilic dermatosis and recurrent …

Имитационное моделирование конформационных изменений мембранного белка KCNQ1 под действием внешнего статического электрического поля

Мамасахлисов Е.Ш. (РАУ, ЕрГУ, ИППФ, Армения), Витя Варданян (Институт молекулярной биологии НАН РА) В качестве модельной системы рассматривался белок представленный в pdb-файле 8SIN (рис. 1), состоящий из четырех мономерных белков. Рис. 1. Белок KCNQ1 в «нижней» конформации Для изучения его конформационных изменений под действием внешнего электрического поля была создана система, …

Enhanced discharge robustness of large-scale resistive WEM detectors with diamond-like carbon anode

V. Bayev, K. Afanaciev, S. Movchan, A. Kashchuk, O. Levitskaya, V. Akulich and V. Konovalov A prototype of the large-scale resistive WEM (Well Electron Multiplier) detector with enhanced discharge robustness was developed, produced and tested. The WEM detector is composed of a perforated board (500 µm thick with drilled holes …

Electronic Properties of Pristine and Doped Graphitic Germanium Carbide Nanomeshes

Majed Abdel Salam Nashaat Moharram AbdelGhani (Sarah Gamal, M. Nashaat, Lobna Salah, Nageh Allam and Ahmed A Maarouf) Graphitic germanium carbide (g-GeC) is a novel material that has recently aroused much interest. Porous g-GeC can be fabricated by forming a lattice of pores in pristine g-GeC. In this work, we systematically …

Buzdin, Shapiro, and chimera steps in φ₀ Josephson junctions

Majed Abdel Salam Nashaat Moharram AbdelGhani (Yu. M. Shukrinov, E. Kovalenko, J. Tekić, K. Kulikov, and M. Nashaat) The unique resonance and locking phenomena in the superconductor-ferromagnet-superconductor φ₀ Josephson junction under external electromagnetic radiation are demonstrated when not just the electric but also the magnetic component of external radiation is taken …

Resonance phenomena in a nanomagnet coupled to a Josephson junction under external periodic drive

Majed Abdel Salam Nashaat Moharram AbdelGhani (K. V. Kulikov, D. V. Anghel, M. Nashaat, M. Dolineanu, M. Sameh, and Yu. M. Shukrinov) We investigate resonance phenomena in a system consisting of a nanomagnet coupled to a Josephson junction under external periodic drive. The coupling in the system leads to the appearance …

Study Defects Formation Mechanism in La₁₋ₓBaₓ MnO₃ Perovskite Manganite by Positron Annihilation Lifetime and Doppler Broadening Spectroscopy

Nguyen Vu Minh Trung (Jabarov, S. H.; Nabiyeva, A. Kh.; Samadov, S. F.; Abiyev, A. S.; Sidorin, A. A.; Trung, N. V. M.; Orlov, O. S.; Mauyey, B.; Trukhanov, S. V.; Trukhanov, A. V.; Mirzayev, M. N.) In this study, La1-xBaxMnO3 (x = 0.03, 0.27, 0.5) solid solutions were synthesized, and their structure and defect incorporation …

Solid-State Crystallization, Oxygen-Vacancy Rich Mesopores and Stable Triad-Silanol Nests in ZSM-5 Catalyst Induced by Electron-Beam Irradiation and Calcination

Nguyen Vu Minh Trung (Nguyen, L. L.; Xuan, T. D.; Van Chung, C.; Nguyen, L. P.; Phuong, N. T.; Hue, P. T.; Hue, N. T. N.; Van Tiep, N.; Trung, N. V. M.; Drozdziel, A.; Turek, M.; Pyszniak, K.; Kiet, H. A. T.; Nguyen, H.-D.; Pham, T.-P. T.; Anh, N. N.; …

Investigating the Impact of Gamma Irradiation and Temperature on Vacancy Formation and Recombination in ZrB₂ Ceramics Using Positron Annihilation Spectroscopy

Nguyen Vu Minh Trung (Samadov, S. F.; Trung, N. V. M.; Donkov, A. A.; Sidorin, A. A.; Orlov, O. S.; Demir, E.; Samedov, O. A.; Jabarov, S. H.; Tiep, N. V.; Popov, E. P.; Mirzayev, M. N.) In the presented work, the mechanism of evolution of defects in the crystalline structure …