Impact of mutations on the stability of SARS-CoV-2 nucleocapsid protein structure

Nelli Muradyan, Vahram Arakelov, Arsen Sargsyan, Adrine Paronyan, Grigor Arakelov, Karen Nazaryan The nucleocapsid (N) protein of SARS-CoV-2 is known to participate in various host cellular processes, including interferon inhibition, RNA interference, apoptosis, and regulation of virus life cycles. Additionally, it has potential as a diagnostic antigen and/or immunogen. Our research focuses on examining structural …

In Silico Study of Pyrin and 14-3-3 Protein Modulation During FMF and PAAND

Adrine Paronyan, Nelli Muradyan, Arsen Sargsyan, Vahram Arakelov, Grigor Arakelov, Karen Nazaryan Familial Mediterranean fever (FMF) is a genetically determined disease transmitted through autosomal recessive inheritance. Recently, a rare but similar disease to FMF, pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND), has been discovered. PAAND is inherited dominantly and is characterized by neutrophilic dermatosis and recurrent …

Имитационное моделирование конформационных изменений мембранного белка KCNQ1 под действием внешнего статического электрического поля

Мамасахлисов Е.Ш. (РАУ, ЕрГУ, ИППФ, Армения), Витя Варданян (Институт молекулярной биологии НАН РА) В качестве модельной системы рассматривался белок представленный в pdb-файле 8SIN (рис. 1), состоящий из четырех мономерных белков. Рис. 1. Белок KCNQ1 в «нижней» конформации Для изучения его конформационных изменений под действием внешнего электрического поля была создана система, …

Enhanced discharge robustness of large-scale resistive WEM detectors with diamond-like carbon anode

V. Bayev, K. Afanaciev, S. Movchan, A. Kashchuk, O. Levitskaya, V. Akulich and V. Konovalov A prototype of the large-scale resistive WEM (Well Electron Multiplier) detector with enhanced discharge robustness was developed, produced and tested. The WEM detector is composed of a perforated board (500 µm thick with drilled holes …

Software of Mongolian IMDT’s computing complex updated in collaboration with MLIT

On 26 July – 9 August 2025, in cooperation with the Meshcheryakov Laboratory of Information Technologies software at the computing center of the Institute of Mathematics and Digital Technology (IMDT), Ulaanbaatar, was updated. The system administration work was performed by MLIT 2nd category software engineer Mikhail Matveev jointly with IMDT specialists. During the visit, …

DCCN-2025

The DCCN-2025 conference will be held under the support of the IEEE (Russia Section Chapter, COM19) and will take place in Moscow, Russia, on 22 – 26 September, 2025 in a hybrid mode (with physical and/or virtual participation). The main idea of the conference is to provide a platform and forum for researchers and developers …

DLCP-2025

The 9th International Conference on Deep Learning in Computational Physics (DLCP-2025) which will be held at the Skobeltsin Institute of Nuclear Physics of Lomonosov Moscow State University (MSU) on July 2-4, 2025. The conference will be held in a mixed format: face-to-face and remote. The conference focuses on the use of machine learning …

GRID’2025

The International Conference “Distributed Computing and Grid-technologies in Science and Education” will take place on 7-11 July 2025 and will be held at the Meshcheryakov Laboratory of Information Technologies (MLIT) of the Joint Institute for Nuclear Research (JINR). The conference GRID 2025 is dedicated to the 115th anniversary of the birth of M.G. Meshcheryakov (1910-1994) and to …

Conference Information and Telecommunication Technologies and Mathematical Modeling of High-Tech Systems 2025 (ITTMM 2025)

It is our pleasure to invite you to attend the XV Conference (with international participation) “Information and Telecommunication Technologies and Mathematical Modeling of High-Tech Systems”. The conference will be held in Moscow, Russia, April 7-11, 2025. Topics The Conference is supposed to take place in the scientific areas formed during the …